Miss Kepler is a science teacher at the school. She was played by Gene Raye Price.
- Barney in Outer Space (first appearance)
- Barney's Halloween Party
- Let's Go to the Zoo (last appearance)
- As she is a science teacher, her name refers to Johannes Kepler (founder of the three laws of planetary motion).
- In Once a Pond a Time, Curtis mentioned that his science teacher created a pond in the playground, but fails to mention a name.
- As revealed in Let's Go to the Zoo, her summer job is a zookeeper.
- Barney didn't talk to miss Kepler until Barney's Halloween Party.
- In Try It, You'll Like It!, Danny mentioned that she likes to do all the talking for the student's presentation for science.